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Aval Científico

  • Jiao J, Yang J, Li Y, Zhang L. Hypertonic saline and seawater solutions damage sinonasal epithelial cell air‐liquid interface cultures. International Forum of Allergy; Rhinology. 2019;10(1):59-68.
  • Sauvalle, M. and Alvo, A., 2018. Effect of the temperature of nasal lavages on mucociliary clearance: a randomised controlled trial. European Archives of Oto-Rhino-Laryngology, 275(9), pp.2403-2406.
  • Piromchai, P., Kasemsiri, Laohasiriwong and Thanaviratananich, 2013. Chronic rhinosinusitis and emerging treatment options. International Journal of General Medicine, p.453.
  • Sindwani, R., 2010. Impact of isotonic and hypertonic saline solutions on mucociliary activity in various nasal pathologies: clinical study. Yearbook of Otolaryngology-Head and Neck Surgery, 2010, pp.205-206.
  • Hauptman, G. and Ryan, M., 2007. The effect of saline solutions on nasal patency and mucociliary clearance in rhinosinusitis patients. Otolaryngology–Head and Neck Surgery, 137(5), pp.815-821.
  • Cohen, N., 2006. Sinonasal Mucociliary Clearance in Health and Disease. Annals of Otology, Rhinology; Laryngology, 115(9), pp.20-26
  • Boek, W., Graamans, K., Natzijl, H., van Rijk, P. and Huizing, E., 2002. Nasal Mucociliary Transport: New Evidence for a Key Role of Ciliary Beat Frequency. The Laryngoscope, 112(3), pp.570-573.
  • Caroline Feliz Fonseca Sepeda da Silva, et al. Symptom assessment after nasal irrigation with xylitol in the postoperative period of endonasal endoscopic surgery. Brazilian Journal of Otorhinolaryngology. 2022;88(2):243-250.
  • Hui N, Yii N, Robinson D. Xylitol nasal preparations in sinonasal disease: a literature review and meta-analysis. Aust J Otolaryngol 2022;5:8.
  • Kim DH, Kim Y, Lim IG, et al. Effect of Postoperative Xylitol Nasal Irrigation on Patients with Sinonasal Diseases. Otolaryngology–Head and Neck Surgery. 2019;160(3):550-555.
  • de Paiva Leite S, Douglas R. How does sinus surgery affect topical irrigation distribution?. Current Opinion in Otolaryngology Head; Neck Surgery. 2018;26(1):21-26.
  • Giotakis A, Karow E, Scheithauer M, Weber R, Riechelmann H. Saline irrigations following sinus surgery a controlled, single blinded, randomized trial. Rhinology journal. 2016;54(4):302-310.
  • Low T, Woods C, Ullah S, Carney A. A Double-Blind Randomized Controlled Trial of Normal Saline, Lactated Ringer’s, and Hypertonic Saline Nasal Irrigation Solution after Endoscopic Sinus Surgery. American Journal of Rhinology; Allergy. 2014;28(3):225-231.
  • Kim S, Sung U, Jung J, Paik J, Woo J, Cha H et al. The Effect of Maxillary Sinus Irrigation on Early Prognostic Factors after Endoscopic Sinus Surgery: A Preliminary Study. American Journal of Rhinology; Allergy. 2013;27(5):e158-e161.
  • Rudmik L, Soler Z, Orlandi R, Stewart M, Bhattacharyya N, Kennedy D et al. Early postoperative care following endoscopic sinus surgery: an evidence-based review with recommendations. International Forum of Allergy & Rhinology.
  • Harvey R, Snidvongs K, Kalish L, Oakley G, Sacks R. Corticosteroid nasal irrigations are more effective than simple sprays in a randomized double-blinded placebo-controlled trial for chronic rhinosinusitis after sinus surgery. International Forum of Allergy; Rhinology. 2018;8(4):461-470.
  • Tugrul S, Dogan R, Eren S, Meric A, Ozturan O. The use of large volume low pressure nasal saline with fluticasone propionate for the treatment of pediatric acute rhinosinusitis. International Journal of Pediatric Otorhinolaryngology. 2014;78(8):1393-1399.
  • Liang J, Lane A.Topical Drug Delivery for Chronic Rhinosinusitis. Current Otorhinolaryngology Reports. 2012;1(1):51-60.
  • Baxter AL, Schwartz KR, Johnson RW, et al. Rapid initiation of nasal saline irrigation to reduce severity in high-risk COVID+ outpatients. Ear Nose Throat J. 2022
  • Radulesco T, Lechien JR, et al. Safety and Impact of Nasal Lavages During Viral Infections Such as SARS-CoV-2. Ear Nose Throat J. 2021 Apr;100(2_suppl):188S-191S. 
  • Singh S, Aggarwal P, Ravichandiran V. Immunological Response of the Respiratory Tract in the SARS-CoV-2 Infection. Coronaviruses. 2021;2(9).
  • Farrell N, Klatt-Cromwell C, Schneider J. Benefits and Safety of Nasal Saline Irrigations in a Pandemic—Washing COVID-19 Away. JAMA Otolaryngology–Head; Neck Surgery. 2020;146(9):787.
  • Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A. Hypertonic saline nasal irrigation and gargling should be considered as a treatment option for COVID-19. Journal of Global Health. 2020;10(1).
  • Ramalingam S, Graham C, Dove J, Morrice L, Sheikh A. A pilot, open labelled, randomised controlled trial of hypertonic saline nasal irrigation and gargling for the common cold. Scientific Reports. 2019;9(1).
  • Piromchai P et al. Squeeze bottle versus syringe nasal saline irrigation for persistent allergic rhinitis – a randomized controlled trial. Rhinology 2020; 58(5):460-464.
  • Gabory L, Kérimian M, Baux Y, Boisson N, Bordenave L. Computational fluid dynamics simulation to compare large volume irrigation and continuous spraying during nasal irrigation. International Forum of Allergy; Rhinology. 2019;10(1):41-48.
  • Piromchai P, Puvatanond C, Kirtsreesakul V, Chaiyasate S, Thanaviratananich S. Effectiveness of nasal irrigation devices: a Thai multicentre survey. PeerJ. 2019;7:e7000.
  • Low TH, Woods CM, Ullah S, Carney AS. A double-blind randomized controlled trial of normal saline, lactated Ringer’s, and hypertonic saline nasal irrigation solution after endoscopic sinus surgery. Am J Rhinol Allergy. 2014 May-Jun;28(3):225-31. doi: 10.2500/ajra.2014.28.4031. Epub 2014 Jan 16. PMID: 24598116.
  • Snidvongs K, Thanaviratananich S. Update on Intranasal Medications in Rhinosinusitis. Current Allergy and Asthma Reports. 2017;17(7).
  • Campos J, Heppt W, Weber R. Nasal douches for diseases of the nose and the paranasal sinuses—a comparative in vitro investigation. European Archives of Oto-Rhino-Laryngology. 2013;270(11):2891-2899.
  • Sindwani R. Nasal saline for chronic sinonasal symptoms: a randomized controlled trial. Yearbook of Otolaryngology-Head and Neck Surgery. 2008;2008:209-210.
  • Wormald P, Cain T, Oates L, Hawke L, Wong I. A Comparative Study of Three Methods of Nasal Irrigation. The Laryngoscope. 2004;114(12):2224-2227.
  • Jung M, Lee JY, Ryu G, Lee KE, Hong SD, Choi J, Kim S, Ahn K, Dhong HJ, Chung SK, Kim J, Kim HY. Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial. Asian Pac J Allergy Immunol. 2020 Dec;38(4):251-257.
  • Chandy Z, Ference E, Lee J. Clinical Guidelines on Chronic Rhinosinusitis in Children. Current Allergy and Asthma Reports. 2019;19(2).
  • Fokkens W, Desrosiers M, Harvey R, et al.EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis. Rhinology. 2019 Jun 1;57(3):162-168. doi: 10.4193/Rhin19.080. PMID: 30810118.
  • Satdhabudha A, Utispan K, Monthanapisut P, Poachanukoon O.A randomized controlled study comparing the efficacy of nasal saline irrigation devices in children with acute rhinosinusitis. Asian Pac J Allergy Immunol. 2017 Jun;35(2):102-107. doi: 10.12932/AP0753. PMID: 27543734.
  • Ragab A, Farahat T, Al-Hendawy G, Samaka R, Ragab S, El-Ghobashy A. Nasal saline irrigation with or without systemic antibiotics in treatment of children with acute rhinosinusitis. International Journal of Pediatric Otorhinolaryngology. 2015;79(12):2178-2186.
  • King D, Mitchell B, Williams CP, Spurling GK. Saline nasal irrigation for acute upper respiratory tract infections. Cochrane Database Syst Rev. 2015 Apr 20;2015(4):CD006821. doi: 10.1002/14651858.CD006821.pub3. PMID: 25892369; PMCID: PMC9475221.
  • Wang YH, Ku MS, Sun HL, Lue KH. Efficacy of nasal irrigation in the treatment of acute sinusitis in atopic children. J Microbiol Immunol Infect. 2014 Feb;47(1):63-9. doi: 10.1016/j.jmii.2012.08.018. Epub 2012 Sep 30. PMID: 23034126.
  • Pham V, Sykes K, Wei J. Long-term outcome of once daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis. The Laryngoscope. 2013;124(4):1000-1007.
  • Jeffe J, Bhushan B, Schroeder J. Nasal saline irrigation in children: A study of compliance and tolerance. International Journal of Pediatric Otorhinolaryngology. 2012;76(3):409-413.
  • Wei J, Sykes K, Johnson P, He J, Mayo M. Safety and efficacy of once-daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis. The Laryngoscope. 2011;121(9):1989-2000.
  • Yun-Hu Wang, Chun-Ping Yang, et al. Efficacy of nasal irrigation in the treatment of acute sinusitis in children. International Journal of Pediatric Otorhinolaryngology, Vol 73, Issue 12,2009,Pages 1696-1701, ISSN 0165-5876.
  • Slapak I, Skoupá J, Strnad P, Horník P. Efficacy of isotonic nasal wash (seawater) in the treatment and prevention of rhinitis in children. Arch Otolaryngol Head Neck Surg. 2008 Jan;134(1):67-74. doi: 10.1001/archoto.2007.19. PMID: 18209140.
  • Ana Martínez-Serrano, Paloma Martínez-Campos, Laura Seijoso-González, Héctor Ruiz-Rojo. Revisión narrativa de la técnica de los lavados nasales en pediatría. Enfermería Clínica, Volume 31, Issue 3,2021, Pages 189-194.
  • Jung M, Lee JY, Ryu G, Lee KE, Hong SD, Choi J, Kim S, Ahn K, Dhong HJ, Chung SK, Kim J, Kim HY. Beneficial effect of nasal saline irrigation in children with allergic rhinitis and asthma: A randomized clinical trial. Asian Pac J Allergy Immunol. 2020 Dec;38(4):251-257.
  • Head K, Snidvongs K, Glew S, Scadding G, Schilder A, Philpott C et al. Saline irrigation for allergic rhinitis. Cochrane Database of Systematic Reviews. 2017.
  • Nguyen S, Psaltis A, Schlosser R. Isotonic Saline Nasal Irrigation is an Effective Adjunctive Therapy to Intranasal Corticosteroid Spray in Allergic Rhinitis. American Journal of Rhinology; Allergy. 2014;28(4):308-311.
  • Roberts G, Xatzipsalti M, et al.Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013 Sep;68(9):1102-16. doi: 10.1111/all.12235. Epub 2013 Aug 19. PMID: 23952296.
  • Wang YH, Ku MS, et al. Efficacy of nasal irrigation in the treatment of acute sinusitis in atopic children. J Microbiol Immunol Infect. 2014 Feb;47(1):63-9. doi: 10.1016/j.jmii.2012.08.018. Epub 2012 Sep 30. PMID: 23034126.
  • Hermelingmeier KE, Weber RK et al. Nasal irrigation as an adjunctive treatment in allergic rhinitis: a systematic review and meta-analysis.  2012 Sep-Oct;26(5):e119-25. doi: 10.2500/ajra.2012.26.3787. PMID: 23168142; PMCID: PMC3904042.
  • Chandy Z, Ference E, Lee J. Clinical Guidelines on Chronic Rhinosinusitis in Children. Current Allergy and Asthma Reports. 2019;19(2).
  • Fokkens W, Desrosiers M, et al. EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis. 2019 Jun 1;57(3):162-168. doi: 10.4193/Rhin19.080. PMID: 30810118.
  • Hopkins C. Chronic Rhinosinusitis with Nasal Polyps. New England Journal of Medicine. 2019;381(1):55-63.
  • Beswick DM, Messner AH, Hwang PH. Pediatric Chronic Rhinosinusitis Management in Rhinologists and Pediatric Otolaryngologists. Ann Otol Rhinol Laryngol. 2017 Sep;126(9):634-639. doi: 10.1177/0003489417719717. Epub 2017 Aug 2. PMID: 28766959.
  • Zakrzewska A. Diagnosis and treatment of Chronic Rhinosinusitis in Children according European Position Paper on Rhinosinusitis and nasal Polyps –EPOS-2012 and American Academy Otolaryngology-Head and Neck Surgery 2014. Polski Przegląd Otorynolaryngologiczny. 2018;7(2):27-32.
  • Rudmik L, Soler Z. Medical Therapies for Adult Chronic Sinusitis. JAMA. 2015;314(9):926.
  • Ragab A, Farahat T, Al-Hendawy G, Samaka R, Ragab S, El-Ghobashy A. Nasal saline irrigation with or without systemic antibiotics in treatment of children with acute rhinosinusitis. International Journal of Pediatric Otorhinolaryngology. 2015;79(12):2178-2186.
  • Pham V, Sykes K, Wei J. Long-term outcome of once daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis. The Laryngoscope. 2013;124(4):1000-1007.
  • Hong SD, Kim JH, Kim HY, Jang MS, Dhong HJ, Chung SK. Compliance and efficacy of saline irrigation in pediatric chronic rhinosinusitis. Auris Nasus Larynx. 2014 Feb;41(1):46-9. doi: 10.1016/j.anl.2013.07.008. Epub 2013 Aug 8. PMID: 23932052.
  • Wei J, Sykes K, Johnson P, He J, Mayo M. Safety and efficacy of once-daily nasal irrigation for the treatment of pediatric chronic rhinosinusitis. The Laryngoscope. 2011;121(9):1989-2000.
  • Jeffe JS, Bhushan B, Schroeder JW Jr.Nasal saline irrigation in children: a study of compliance and tolerance. Int J Pediatr Otorhinolaryngol. 2012 Mar;76(3):409-13. doi: 10.1016/j.ijporl.2011.12.022. Epub 2012 Jan 21. PMID: 22266167.
  • Rosenfeld R. Clinical Practice Guideline on Adult Sinusitis. Otolaryngology–Head and Neck Surgery. 2007;137(3):365-377.
  • Scadding G, Durham S, Mirakian R, Jones N, Drake-Lee A, Ryan D et al. BSACI guidelines for the management of rhinosinusitis and nasal polyposis. Clinical; Experimental Allergy. 2007;38(2):260-275.
  • Caroline Feliz Fonseca Sepeda da Silva, et al.Symptom assessment after nasal irrigation with xylitol in the postoperative period of endonasal endoscopic surgery. Brazilian Journal of Otorhinolaryngology. 2022;88(2):243-250.
  • Hui N, Yii N, Robinson D. Xylitol nasal preparations in sinonasal disease: a literature review and meta-analysis. Aust J Otolaryngol 2022;5:8.
  • Fokkens W, Desrosiers M, et al. EPOS2020: development strategy and goals for the latest European Position Paper on Rhinosinusitis. Rhinology. 2019 Jun 1;57(3):162-168. doi: 10.4193/Rhin19.080. PMID: 30810118.
  • Lin L, Tang X, Wei J, Dai F, Sun G. Xylitol nasal irrigation in the treatment of chronic rhinosinusitis. American Journal of Otolaryngology. 2017;38(4):383-389.
  • Weissman J, Fernandez F, Hwang P. Xylitol nasal irrigation in the management of chronic rhinosinusitis: A pilot study. The Laryngoscope. 2011;121(11):2468-2472.
  • Kontiokari T. Antiadhesive effects of xylitol on otopathogenic bacteria. Journal of Antimicrobial Chemotherapy. 1998;41(5):563-565.